CHRONIC OBSTRUCTIVE PULMONARY DISEASE Muscle fibre type shifting in the vastus lateralis of patients with COPD is associated with disease severity: a systematic review and meta-analysis
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s 30 14 (10/4) 61 (9) 24 (4) 38 (11) – 46 (13) 45 (26) – 38 (14) 18 (8) 45 (11) IHC 31/32** 47 (47/0) 67 (8)* ** 24 (?)*1** 40 (12)* ** – 41 (11)*`** 48 (22)*1** 9.2 (1.8)* ** 42 (8)* 27 (5)* 29 (7)* HC 33/34** 29 (29/0) 66 (6)** 24 (3)** 42 (13)** 66 (17)** 62 (18) ** – 9.1 (1.0)** 39 (22) 36 (17) 29 (16) HC N, study group size; BMI, body mass index; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; TLCO, carbon monoxide transfer factor; HC, histochemistry; IHC, immunohistochemistry; SDS PAGE, gel electrophoresis analysis of myosin heavy chain isoforms; ? indicates that the data were not given or could not be calculated. *Calculated from combined subgroups. Additional data obtained from authors through personal communication, used with permission. `Vital capacity instead of forced vital capacity. 1Calculated from average data as presented in the paper. Not all subjects had a muscle biopsy. **Data obtained from a related publication. Determined in a figure. ``Sum of fibre type proportions is not 100% because (small) proportions of hybrid fibres were excluded from analysis. Muscle fibre type shifting in patients with COPD 945 www.thoraxjnl.com group.bmj.com on April 5, 2017 Published by http://thorax.bmj.com/ Downloaded from
منابع مشابه
Muscle fibre type shifting in the vastus lateralis of patients with COPD is associated with disease severity: a systematic review and meta-analysis.
BACKGROUND Skeletal muscle dysfunction is a common feature in chronic obstructive pulmonary disease (COPD) which is associated with intrinsic muscular abnormalities. One of the most consistently reported alterations is a shift from fibre type I to II in the vastus lateralis of these patients. Surprisingly, the relationship between this shift and the severity and phenotype of COPD remains unclea...
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تاریخ انتشار 2007